ChloroquineV1, Main, Exploration, bibRecord, 001765

Antimalarial activities of ferroquine conjugates with either glutathione reductase inhibitors or glutathione depletors via a hydrolyzable amide linker

Identifieur interne : 001765 ( Main/Exploration ); précédent : 001764; suivant : 001766

Antimalarial activities of ferroquine conjugates with either glutathione reductase inhibitors or glutathione depletors via a hydrolyzable amide linker

Auteurs : Natascha Chavain [France] ; Elisabeth Davioud-Charvet [Allemagne] ; Xavier Trivelli [France] ; Linda Mbeki [France] ; M. Rottmann [Suisse] ; R. Brun [Suisse] ; Christophe Biot [France]

Source :

Bioorganic and Medicinal Chemistry [ 0968-0896 ] ; 2009-12-01.

RBID : Hal:hal-00642006

Abstract

Based on the prodrug concept as well as the combination of two different classes of antimalarial agents, we designed and synthesized two series of ferrocenic antimalarial dual molecules consisting of a ferroquine analogue conjugated with a glutathione reductase inhibitor (or a glutathione depletor) through a cleavable amide bond in order to target two essential pathways in the malarial parasites. The results showed no enhancement of the antimalarial activity of the dual molecules but evidenced a unique mode of action of ferroquine and ferrocenyl analogues distinct of those of chloroquine and nonferrocenic 4-aminoquinoline analogues.

Url:

https://hal.archives-ouvertes.fr/hal-00642006

DOI: 10.1016/j.bmc.2009.10.008

Affiliations:

Allemagne, France, Suisse

Links toward previous steps (curation, corpus...)

to stream Hal, to step Corpus: 000018
to stream Hal, to step Curation: 000018
to stream Hal, to step Checkpoint: 000193
to stream Main, to step Merge: 001769
to stream Main, to step Curation: 001765

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Antimalarial activities of ferroquine conjugates with either glutathione reductase inhibitors or glutathione depletors via a hydrolyzable amide linker</title>
<author><name sortKey="Chavain, Natascha" sort="Chavain, Natascha" uniqKey="Chavain N" first="Natascha" last="Chavain">Natascha Chavain</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-3209" status="VALID">          <idno type="IdRef">161608809</idno>
          <idno type="ISNI">0000 0004 0368 3038</idno>
          <idno type="RNSR">200612828X</idno>
          <orgName>Unité de Catalyse et de Chimie du Solide - UMR 8181</orgName>
          <orgName type="acronym">UCCS</orgName>
          <desc>            <address>              <addrLine>Cité Scientifique - Bâtiment C3 59655 Villeneuve d'Ascq Cedex</addrLine>
              <country key="FR"></country>
            </address>
          </desc>
          <listRelation>            <relation active="#struct-56711" type="direct"></relation>
            <relation active="#struct-120930" type="direct"></relation>
            <relation active="#struct-300369" type="direct"></relation>
            <relation active="#struct-374570" type="direct"></relation>
            <relation name="UMR8181" active="#struct-441569" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-56711" type="direct"><org type="institution" xml:id="struct-56711" status="VALID">          <orgName>Université d'Artois</orgName>
          <orgName type="acronym">UA</orgName>
          <desc>            <address>              <addrLine>9 rue du Temple - BP 10665 - 62030 Arras cedex</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.univ-artois.fr/</ref>
          </desc>
        </org>
</tutelle>
<tutelle active="#struct-120930" type="direct"><org type="institution" xml:id="struct-120930" status="VALID">          <orgName>Ecole Centrale de Lille</orgName>
          <desc>            <address>              <addrLine>Cité Scientifique - CS 20048 59651 Villeneuve d'Ascq Cedex</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.ec-lille.fr/</ref>
          </desc>
        </org>
</tutelle>
<tutelle active="#struct-300369" type="direct"><org type="institution" xml:id="struct-300369" status="VALID">          <orgName>Ecole Nationale Supérieure de Chimie de Lille</orgName>
          <orgName type="acronym">ENSCL</orgName>
          <desc>            <address>              <addrLine>Cité ScientifiqueBât. C7Avenue MendeleïevCS 9010859652 VILLENEUVE D’ASCQ CEDEX</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.ensc-lille.fr</ref>
          </desc>
        </org>
</tutelle>
<tutelle active="#struct-374570" type="direct"><org type="institution" xml:id="struct-374570" status="VALID">          <idno type="IdRef">223446556</idno>
          <orgName>Université de Lille</orgName>
          <date type="start">2018-01-01</date>
          <desc>            <address>              <addrLine>Lille</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">https://www.univ-lille.fr/</ref>
          </desc>
        </org>
</tutelle>
<tutelle name="UMR8181" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.cnrs.fr/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Davioud Charvet, Elisabeth" sort="Davioud Charvet, Elisabeth" uniqKey="Davioud Charvet E" first="Elisabeth" last="Davioud-Charvet">Elisabeth Davioud-Charvet</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-174255" status="INCOMING">          <orgName>Biochemie-Zentrum</orgName>
          <desc>            <address>              <addrLine>Im Neuenheimer Feld 504, D-69120 Heidelberg</addrLine>
              <country key="DE"></country>
            </address>
          </desc>
          <listRelation>            <relation active="#struct-344084" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-344084" type="direct"><org type="institution" xml:id="struct-344084" status="INCOMING">          <orgName>Heidelberg Universität</orgName>
          <desc>            <address>              <country key="FR"></country>
            </address>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>Allemagne</country>
</affiliation>
</author>
<author><name sortKey="Trivelli, Xavier" sort="Trivelli, Xavier" uniqKey="Trivelli X" first="Xavier" last="Trivelli">Xavier Trivelli</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-1330" status="OLD">          <idno type="IdRef">134442571</idno>
          <idno type="ISNI">0000 0004 0638 7509</idno>
          <idno type="RNSR">199812904P</idno>
          <orgName>Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576</orgName>
          <orgName type="acronym">UGSF</orgName>
          <date type="end">2019-12-31</date>
          <desc>            <address>              <addrLine>Université de Lille Sciences et technologies - UMR8576 CNRS Cité Scientifique - Bâtiment C9 F-59655 Villeneuve d’Ascq Cedex</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://ugsf-umr-glycobiologie.univ-lille1.fr/</ref>
          </desc>
          <listRelation>            <relation active="#struct-374570" type="direct"></relation>
            <relation name="UMR8576" active="#struct-441569" type="direct"></relation>
            <relation name="USC1409" active="#struct-92114" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-374570" type="direct"><org type="institution" xml:id="struct-374570" status="VALID">          <idno type="IdRef">223446556</idno>
          <orgName>Université de Lille</orgName>
          <date type="start">2018-01-01</date>
          <desc>            <address>              <addrLine>Lille</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">https://www.univ-lille.fr/</ref>
          </desc>
        </org>
</tutelle>
<tutelle name="UMR8576" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.cnrs.fr/</ref>
          </desc>
        </org>
</tutelle>
<tutelle name="USC1409" active="#struct-92114" type="direct"><org type="institution" xml:id="struct-92114" status="OLD">          <orgName>Institut National de la Recherche Agronomique</orgName>
          <orgName type="acronym">INRA</orgName>
          <date type="start">1946-05-18</date>
          <date type="end">2019-12-31</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.inra.fr</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Mbeki, Linda" sort="Mbeki, Linda" uniqKey="Mbeki L" first="Linda" last="Mbeki">Linda Mbeki</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-3209" status="VALID">          <idno type="IdRef">161608809</idno>
          <idno type="ISNI">0000 0004 0368 3038</idno>
          <idno type="RNSR">200612828X</idno>
          <orgName>Unité de Catalyse et de Chimie du Solide - UMR 8181</orgName>
          <orgName type="acronym">UCCS</orgName>
          <desc>            <address>              <addrLine>Cité Scientifique - Bâtiment C3 59655 Villeneuve d'Ascq Cedex</addrLine>
              <country key="FR"></country>
            </address>
          </desc>
          <listRelation>            <relation active="#struct-56711" type="direct"></relation>
            <relation active="#struct-120930" type="direct"></relation>
            <relation active="#struct-300369" type="direct"></relation>
            <relation active="#struct-374570" type="direct"></relation>
            <relation name="UMR8181" active="#struct-441569" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-56711" type="direct"><org type="institution" xml:id="struct-56711" status="VALID">          <orgName>Université d'Artois</orgName>
          <orgName type="acronym">UA</orgName>
          <desc>            <address>              <addrLine>9 rue du Temple - BP 10665 - 62030 Arras cedex</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.univ-artois.fr/</ref>
          </desc>
        </org>
</tutelle>
<tutelle active="#struct-120930" type="direct"><org type="institution" xml:id="struct-120930" status="VALID">          <orgName>Ecole Centrale de Lille</orgName>
          <desc>            <address>              <addrLine>Cité Scientifique - CS 20048 59651 Villeneuve d'Ascq Cedex</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.ec-lille.fr/</ref>
          </desc>
        </org>
</tutelle>
<tutelle active="#struct-300369" type="direct"><org type="institution" xml:id="struct-300369" status="VALID">          <orgName>Ecole Nationale Supérieure de Chimie de Lille</orgName>
          <orgName type="acronym">ENSCL</orgName>
          <desc>            <address>              <addrLine>Cité ScientifiqueBât. C7Avenue MendeleïevCS 9010859652 VILLENEUVE D’ASCQ CEDEX</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.ensc-lille.fr</ref>
          </desc>
        </org>
</tutelle>
<tutelle active="#struct-374570" type="direct"><org type="institution" xml:id="struct-374570" status="VALID">          <idno type="IdRef">223446556</idno>
          <orgName>Université de Lille</orgName>
          <date type="start">2018-01-01</date>
          <desc>            <address>              <addrLine>Lille</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">https://www.univ-lille.fr/</ref>
          </desc>
        </org>
</tutelle>
<tutelle name="UMR8181" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.cnrs.fr/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Rottmann, M" sort="Rottmann, M" uniqKey="Rottmann M" first="M." last="Rottmann">M. Rottmann</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-174256" status="INCOMING">          <orgName>Swiss Tropical Institute</orgName>
          <desc>            <address>              <addrLine>Socinstrasse 57 PO Box, CH-4002 Basel</addrLine>
              <country key="CH"></country>
            </address>
          </desc>
          <listRelation>            <relation active="#struct-304965" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-304965" type="direct"><org type="institution" xml:id="struct-304965" status="INCOMING">          <orgName>AUTRES</orgName>
          <desc>            <address>              <country key="FR"></country>
            </address>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>Suisse</country>
</affiliation>
</author>
<author><name sortKey="Brun, R" sort="Brun, R" uniqKey="Brun R" first="R." last="Brun">R. Brun</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-174256" status="INCOMING">          <orgName>Swiss Tropical Institute</orgName>
          <desc>            <address>              <addrLine>Socinstrasse 57 PO Box, CH-4002 Basel</addrLine>
              <country key="CH"></country>
            </address>
          </desc>
          <listRelation>            <relation active="#struct-304965" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-304965" type="direct"><org type="institution" xml:id="struct-304965" status="INCOMING">          <orgName>AUTRES</orgName>
          <desc>            <address>              <country key="FR"></country>
            </address>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>Suisse</country>
</affiliation>
</author>
<author><name sortKey="Biot, Christophe" sort="Biot, Christophe" uniqKey="Biot C" first="Christophe" last="Biot">Christophe Biot</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-3209" status="VALID">          <idno type="IdRef">161608809</idno>
          <idno type="ISNI">0000 0004 0368 3038</idno>
          <idno type="RNSR">200612828X</idno>
          <orgName>Unité de Catalyse et de Chimie du Solide - UMR 8181</orgName>
          <orgName type="acronym">UCCS</orgName>
          <desc>            <address>              <addrLine>Cité Scientifique - Bâtiment C3 59655 Villeneuve d'Ascq Cedex</addrLine>
              <country key="FR"></country>
            </address>
          </desc>
          <listRelation>            <relation active="#struct-56711" type="direct"></relation>
            <relation active="#struct-120930" type="direct"></relation>
            <relation active="#struct-300369" type="direct"></relation>
            <relation active="#struct-374570" type="direct"></relation>
            <relation name="UMR8181" active="#struct-441569" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-56711" type="direct"><org type="institution" xml:id="struct-56711" status="VALID">          <orgName>Université d'Artois</orgName>
          <orgName type="acronym">UA</orgName>
          <desc>            <address>              <addrLine>9 rue du Temple - BP 10665 - 62030 Arras cedex</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.univ-artois.fr/</ref>
          </desc>
        </org>
</tutelle>
<tutelle active="#struct-120930" type="direct"><org type="institution" xml:id="struct-120930" status="VALID">          <orgName>Ecole Centrale de Lille</orgName>
          <desc>            <address>              <addrLine>Cité Scientifique - CS 20048 59651 Villeneuve d'Ascq Cedex</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.ec-lille.fr/</ref>
          </desc>
        </org>
</tutelle>
<tutelle active="#struct-300369" type="direct"><org type="institution" xml:id="struct-300369" status="VALID">          <orgName>Ecole Nationale Supérieure de Chimie de Lille</orgName>
          <orgName type="acronym">ENSCL</orgName>
          <desc>            <address>              <addrLine>Cité ScientifiqueBât. C7Avenue MendeleïevCS 9010859652 VILLENEUVE D’ASCQ CEDEX</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.ensc-lille.fr</ref>
          </desc>
        </org>
</tutelle>
<tutelle active="#struct-374570" type="direct"><org type="institution" xml:id="struct-374570" status="VALID">          <idno type="IdRef">223446556</idno>
          <orgName>Université de Lille</orgName>
          <date type="start">2018-01-01</date>
          <desc>            <address>              <addrLine>Lille</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">https://www.univ-lille.fr/</ref>
          </desc>
        </org>
</tutelle>
<tutelle name="UMR8181" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.cnrs.fr/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">HAL</idno>
<idno type="RBID">Hal:hal-00642006</idno>
<idno type="halId">hal-00642006</idno>
<idno type="halUri">https://hal.archives-ouvertes.fr/hal-00642006</idno>
<idno type="url">https://hal.archives-ouvertes.fr/hal-00642006</idno>
<idno type="doi">10.1016/j.bmc.2009.10.008</idno>
<date when="2009-12-01">2009-12-01</date>
<idno type="wicri:Area/Hal/Corpus">000018</idno>
<idno type="wicri:Area/Hal/Curation">000018</idno>
<idno type="wicri:Area/Hal/Checkpoint">000193</idno>
<idno type="wicri:explorRef" wicri:stream="Hal" wicri:step="Checkpoint">000193</idno>
<idno type="wicri:doubleKey">0968-0896:2009:Chavain N:antimalarial:activities:of</idno>
<idno type="wicri:Area/Main/Merge">001769</idno>
<idno type="wicri:Area/Main/Curation">001765</idno>
<idno type="wicri:Area/Main/Exploration">001765</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Antimalarial activities of ferroquine conjugates with either glutathione reductase inhibitors or glutathione depletors via a hydrolyzable amide linker</title>
<author><name sortKey="Chavain, Natascha" sort="Chavain, Natascha" uniqKey="Chavain N" first="Natascha" last="Chavain">Natascha Chavain</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-3209" status="VALID">          <idno type="IdRef">161608809</idno>
          <idno type="ISNI">0000 0004 0368 3038</idno>
          <idno type="RNSR">200612828X</idno>
          <orgName>Unité de Catalyse et de Chimie du Solide - UMR 8181</orgName>
          <orgName type="acronym">UCCS</orgName>
          <desc>            <address>              <addrLine>Cité Scientifique - Bâtiment C3 59655 Villeneuve d'Ascq Cedex</addrLine>
              <country key="FR"></country>
            </address>
          </desc>
          <listRelation>            <relation active="#struct-56711" type="direct"></relation>
            <relation active="#struct-120930" type="direct"></relation>
            <relation active="#struct-300369" type="direct"></relation>
            <relation active="#struct-374570" type="direct"></relation>
            <relation name="UMR8181" active="#struct-441569" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-56711" type="direct"><org type="institution" xml:id="struct-56711" status="VALID">          <orgName>Université d'Artois</orgName>
          <orgName type="acronym">UA</orgName>
          <desc>            <address>              <addrLine>9 rue du Temple - BP 10665 - 62030 Arras cedex</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.univ-artois.fr/</ref>
          </desc>
        </org>
</tutelle>
<tutelle active="#struct-120930" type="direct"><org type="institution" xml:id="struct-120930" status="VALID">          <orgName>Ecole Centrale de Lille</orgName>
          <desc>            <address>              <addrLine>Cité Scientifique - CS 20048 59651 Villeneuve d'Ascq Cedex</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.ec-lille.fr/</ref>
          </desc>
        </org>
</tutelle>
<tutelle active="#struct-300369" type="direct"><org type="institution" xml:id="struct-300369" status="VALID">          <orgName>Ecole Nationale Supérieure de Chimie de Lille</orgName>
          <orgName type="acronym">ENSCL</orgName>
          <desc>            <address>              <addrLine>Cité ScientifiqueBât. C7Avenue MendeleïevCS 9010859652 VILLENEUVE D’ASCQ CEDEX</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.ensc-lille.fr</ref>
          </desc>
        </org>
</tutelle>
<tutelle active="#struct-374570" type="direct"><org type="institution" xml:id="struct-374570" status="VALID">          <idno type="IdRef">223446556</idno>
          <orgName>Université de Lille</orgName>
          <date type="start">2018-01-01</date>
          <desc>            <address>              <addrLine>Lille</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">https://www.univ-lille.fr/</ref>
          </desc>
        </org>
</tutelle>
<tutelle name="UMR8181" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.cnrs.fr/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Davioud Charvet, Elisabeth" sort="Davioud Charvet, Elisabeth" uniqKey="Davioud Charvet E" first="Elisabeth" last="Davioud-Charvet">Elisabeth Davioud-Charvet</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-174255" status="INCOMING">          <orgName>Biochemie-Zentrum</orgName>
          <desc>            <address>              <addrLine>Im Neuenheimer Feld 504, D-69120 Heidelberg</addrLine>
              <country key="DE"></country>
            </address>
          </desc>
          <listRelation>            <relation active="#struct-344084" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-344084" type="direct"><org type="institution" xml:id="struct-344084" status="INCOMING">          <orgName>Heidelberg Universität</orgName>
          <desc>            <address>              <country key="FR"></country>
            </address>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>Allemagne</country>
</affiliation>
</author>
<author><name sortKey="Trivelli, Xavier" sort="Trivelli, Xavier" uniqKey="Trivelli X" first="Xavier" last="Trivelli">Xavier Trivelli</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-1330" status="OLD">          <idno type="IdRef">134442571</idno>
          <idno type="ISNI">0000 0004 0638 7509</idno>
          <idno type="RNSR">199812904P</idno>
          <orgName>Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576</orgName>
          <orgName type="acronym">UGSF</orgName>
          <date type="end">2019-12-31</date>
          <desc>            <address>              <addrLine>Université de Lille Sciences et technologies - UMR8576 CNRS Cité Scientifique - Bâtiment C9 F-59655 Villeneuve d’Ascq Cedex</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://ugsf-umr-glycobiologie.univ-lille1.fr/</ref>
          </desc>
          <listRelation>            <relation active="#struct-374570" type="direct"></relation>
            <relation name="UMR8576" active="#struct-441569" type="direct"></relation>
            <relation name="USC1409" active="#struct-92114" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-374570" type="direct"><org type="institution" xml:id="struct-374570" status="VALID">          <idno type="IdRef">223446556</idno>
          <orgName>Université de Lille</orgName>
          <date type="start">2018-01-01</date>
          <desc>            <address>              <addrLine>Lille</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">https://www.univ-lille.fr/</ref>
          </desc>
        </org>
</tutelle>
<tutelle name="UMR8576" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.cnrs.fr/</ref>
          </desc>
        </org>
</tutelle>
<tutelle name="USC1409" active="#struct-92114" type="direct"><org type="institution" xml:id="struct-92114" status="OLD">          <orgName>Institut National de la Recherche Agronomique</orgName>
          <orgName type="acronym">INRA</orgName>
          <date type="start">1946-05-18</date>
          <date type="end">2019-12-31</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.inra.fr</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Mbeki, Linda" sort="Mbeki, Linda" uniqKey="Mbeki L" first="Linda" last="Mbeki">Linda Mbeki</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-3209" status="VALID">          <idno type="IdRef">161608809</idno>
          <idno type="ISNI">0000 0004 0368 3038</idno>
          <idno type="RNSR">200612828X</idno>
          <orgName>Unité de Catalyse et de Chimie du Solide - UMR 8181</orgName>
          <orgName type="acronym">UCCS</orgName>
          <desc>            <address>              <addrLine>Cité Scientifique - Bâtiment C3 59655 Villeneuve d'Ascq Cedex</addrLine>
              <country key="FR"></country>
            </address>
          </desc>
          <listRelation>            <relation active="#struct-56711" type="direct"></relation>
            <relation active="#struct-120930" type="direct"></relation>
            <relation active="#struct-300369" type="direct"></relation>
            <relation active="#struct-374570" type="direct"></relation>
            <relation name="UMR8181" active="#struct-441569" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-56711" type="direct"><org type="institution" xml:id="struct-56711" status="VALID">          <orgName>Université d'Artois</orgName>
          <orgName type="acronym">UA</orgName>
          <desc>            <address>              <addrLine>9 rue du Temple - BP 10665 - 62030 Arras cedex</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.univ-artois.fr/</ref>
          </desc>
        </org>
</tutelle>
<tutelle active="#struct-120930" type="direct"><org type="institution" xml:id="struct-120930" status="VALID">          <orgName>Ecole Centrale de Lille</orgName>
          <desc>            <address>              <addrLine>Cité Scientifique - CS 20048 59651 Villeneuve d'Ascq Cedex</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.ec-lille.fr/</ref>
          </desc>
        </org>
</tutelle>
<tutelle active="#struct-300369" type="direct"><org type="institution" xml:id="struct-300369" status="VALID">          <orgName>Ecole Nationale Supérieure de Chimie de Lille</orgName>
          <orgName type="acronym">ENSCL</orgName>
          <desc>            <address>              <addrLine>Cité ScientifiqueBât. C7Avenue MendeleïevCS 9010859652 VILLENEUVE D’ASCQ CEDEX</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.ensc-lille.fr</ref>
          </desc>
        </org>
</tutelle>
<tutelle active="#struct-374570" type="direct"><org type="institution" xml:id="struct-374570" status="VALID">          <idno type="IdRef">223446556</idno>
          <orgName>Université de Lille</orgName>
          <date type="start">2018-01-01</date>
          <desc>            <address>              <addrLine>Lille</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">https://www.univ-lille.fr/</ref>
          </desc>
        </org>
</tutelle>
<tutelle name="UMR8181" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.cnrs.fr/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Rottmann, M" sort="Rottmann, M" uniqKey="Rottmann M" first="M." last="Rottmann">M. Rottmann</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-174256" status="INCOMING">          <orgName>Swiss Tropical Institute</orgName>
          <desc>            <address>              <addrLine>Socinstrasse 57 PO Box, CH-4002 Basel</addrLine>
              <country key="CH"></country>
            </address>
          </desc>
          <listRelation>            <relation active="#struct-304965" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-304965" type="direct"><org type="institution" xml:id="struct-304965" status="INCOMING">          <orgName>AUTRES</orgName>
          <desc>            <address>              <country key="FR"></country>
            </address>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>Suisse</country>
</affiliation>
</author>
<author><name sortKey="Brun, R" sort="Brun, R" uniqKey="Brun R" first="R." last="Brun">R. Brun</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-174256" status="INCOMING">          <orgName>Swiss Tropical Institute</orgName>
          <desc>            <address>              <addrLine>Socinstrasse 57 PO Box, CH-4002 Basel</addrLine>
              <country key="CH"></country>
            </address>
          </desc>
          <listRelation>            <relation active="#struct-304965" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-304965" type="direct"><org type="institution" xml:id="struct-304965" status="INCOMING">          <orgName>AUTRES</orgName>
          <desc>            <address>              <country key="FR"></country>
            </address>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>Suisse</country>
</affiliation>
</author>
<author><name sortKey="Biot, Christophe" sort="Biot, Christophe" uniqKey="Biot C" first="Christophe" last="Biot">Christophe Biot</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-3209" status="VALID">          <idno type="IdRef">161608809</idno>
          <idno type="ISNI">0000 0004 0368 3038</idno>
          <idno type="RNSR">200612828X</idno>
          <orgName>Unité de Catalyse et de Chimie du Solide - UMR 8181</orgName>
          <orgName type="acronym">UCCS</orgName>
          <desc>            <address>              <addrLine>Cité Scientifique - Bâtiment C3 59655 Villeneuve d'Ascq Cedex</addrLine>
              <country key="FR"></country>
            </address>
          </desc>
          <listRelation>            <relation active="#struct-56711" type="direct"></relation>
            <relation active="#struct-120930" type="direct"></relation>
            <relation active="#struct-300369" type="direct"></relation>
            <relation active="#struct-374570" type="direct"></relation>
            <relation name="UMR8181" active="#struct-441569" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-56711" type="direct"><org type="institution" xml:id="struct-56711" status="VALID">          <orgName>Université d'Artois</orgName>
          <orgName type="acronym">UA</orgName>
          <desc>            <address>              <addrLine>9 rue du Temple - BP 10665 - 62030 Arras cedex</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.univ-artois.fr/</ref>
          </desc>
        </org>
</tutelle>
<tutelle active="#struct-120930" type="direct"><org type="institution" xml:id="struct-120930" status="VALID">          <orgName>Ecole Centrale de Lille</orgName>
          <desc>            <address>              <addrLine>Cité Scientifique - CS 20048 59651 Villeneuve d'Ascq Cedex</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.ec-lille.fr/</ref>
          </desc>
        </org>
</tutelle>
<tutelle active="#struct-300369" type="direct"><org type="institution" xml:id="struct-300369" status="VALID">          <orgName>Ecole Nationale Supérieure de Chimie de Lille</orgName>
          <orgName type="acronym">ENSCL</orgName>
          <desc>            <address>              <addrLine>Cité ScientifiqueBât. C7Avenue MendeleïevCS 9010859652 VILLENEUVE D’ASCQ CEDEX</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.ensc-lille.fr</ref>
          </desc>
        </org>
</tutelle>
<tutelle active="#struct-374570" type="direct"><org type="institution" xml:id="struct-374570" status="VALID">          <idno type="IdRef">223446556</idno>
          <orgName>Université de Lille</orgName>
          <date type="start">2018-01-01</date>
          <desc>            <address>              <addrLine>Lille</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">https://www.univ-lille.fr/</ref>
          </desc>
        </org>
</tutelle>
<tutelle name="UMR8181" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.cnrs.fr/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
</analytic>
<idno type="DOI">10.1016/j.bmc.2009.10.008</idno>
<series><title level="j">Bioorganic and Medicinal Chemistry</title>
<idno type="ISSN">0968-0896</idno>
<imprint><date type="datePub">2009-12-01</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">              <p>Based on the prodrug concept as well as the combination of two different classes of antimalarial agents, we designed and synthesized two series of ferrocenic antimalarial dual molecules consisting of a ferroquine analogue conjugated with a glutathione reductase inhibitor (or a glutathione depletor) through a cleavable amide bond in order to target two essential pathways in the malarial parasites. The results showed no enhancement of the antimalarial activity of the dual molecules but evidenced a unique mode of action of ferroquine and ferrocenyl analogues distinct of those of chloroquine and nonferrocenic 4-aminoquinoline analogues.</p>
            </div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>France</li>
<li>Suisse</li>
</country>
</list>
<tree><country name="France"><noRegion><name sortKey="Chavain, Natascha" sort="Chavain, Natascha" uniqKey="Chavain N" first="Natascha" last="Chavain">Natascha Chavain</name>
</noRegion>
<name sortKey="Biot, Christophe" sort="Biot, Christophe" uniqKey="Biot C" first="Christophe" last="Biot">Christophe Biot</name>
<name sortKey="Mbeki, Linda" sort="Mbeki, Linda" uniqKey="Mbeki L" first="Linda" last="Mbeki">Linda Mbeki</name>
<name sortKey="Trivelli, Xavier" sort="Trivelli, Xavier" uniqKey="Trivelli X" first="Xavier" last="Trivelli">Xavier Trivelli</name>
</country>
<country name="Allemagne"><noRegion><name sortKey="Davioud Charvet, Elisabeth" sort="Davioud Charvet, Elisabeth" uniqKey="Davioud Charvet E" first="Elisabeth" last="Davioud-Charvet">Elisabeth Davioud-Charvet</name>
</noRegion>
</country>
<country name="Suisse"><noRegion><name sortKey="Rottmann, M" sort="Rottmann, M" uniqKey="Rottmann M" first="M." last="Rottmann">M. Rottmann</name>
</noRegion>
<name sortKey="Brun, R" sort="Brun, R" uniqKey="Brun R" first="R." last="Brun">R. Brun</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001765 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001765 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    ChloroquineV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     Hal:hal-00642006
   |texte=   Antimalarial activities of ferroquine conjugates with either glutathione reductase inhibitors or glutathione depletors via a hydrolyzable amide linker
}}

This area was generated with Dilib version V0.6.33.
Data generation: Wed Mar 25 22:43:59 2020. Site generation: Sun Jan 31 12:44:45 2021

	Serveur d'exploration Chloroquine
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration Chloroquine

Antimalarial activities of ferroquine conjugates with either glutathione reductase inhibitors or glutathione depletors via a hydrolyzable amide linker

Antimalarial activities of ferroquine conjugates with either glutathione reductase inhibitors or glutathione depletors via a hydrolyzable amide linker

Source :

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri